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The Domesday Book ofKWJ · AI

Anthropic SDK vs OpenAI Assistants API

Anthropic SDK for maximum control; Assistants API for managed state without infrastructure.

Anthropic SDK / Managed Agents
Building blocks for custom agents — tool use, prompt caching, batch API, extended thinking, memory.

Use this when

Custom loops, prompt caching, batch API, fine-grained control.

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OpenAI Assistants API
OpenAI's hosted agent runtime. Threads, tools, file search, code interpreter — managed for you.

Use this when

Managed threads, built-in file search, code interpreter sandbox.

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Cost comparison

Both per-token. Assistants API adds storage costs.